After the events of GTA III, in the dark setting of Liberty City, gangs has increased the number of SPANK around the streets to gain some cash. However the Leaders compete with each other and try to sabotage the opposing team.
The South Side Hood gang has no connection with drug business but they are targeted by Mafia (Leones) because they believe that someone from the Hood has murdered their formal leader at the time. (Toni Cipriani) The Mafia constantly tries to take out the Hood gang, but the Hoods stand up for themselves.
As a young adult, with the name of Manny Robinson, you go and explore the streets of Vice City to find out what the VCPD want from the Ballas with the help of Grove, Yakuza, and the Triads.

All Manny wanted was to run a gang of his own instead of sharing one with his brother, Tommy. But he has no choice but to defend their own turf and not let the "Italian dogs" ruin his dreams.